Protein Carbamylation in Neurodegeneration and other age-related disorders

Ageing is a complex process that greatly influenced by environmental and genetic factors. at the cellular molecular level characterized accumulation of post-translationally modified proteins are derogative to cells, termed Degenerative protein modification (DPM). A particular class DPM, occurring under impact urea, brain ureido degenerative post-translational modifications (uDPM) has also been implicated in pathogenesis Alzheimer's disease related neurodegenerative disorders. These can disrupt normal functions altering their conformation, enzymatic activities, receptor recognitions, physiological capabilities. Carbamylation an age-related uDPM results from non-enzymatic amino groups ε-amino on lysine proteins. The significance carbamylation some disorders such as cataracts, rheumatoid arthritis,and cardiovascular diseases well documented.However, role various disorders, which age-dependent, not explored much. aim current article retrospection carbamylation, its effect proteins, implications ageing diseases. one uDPM, lysines or N-terminal present peptides isocyanate. arthritis, documented. However, This mini-review will focus relationship between provide overview contribution towards protein, involvement neurodegeneration associated with ageing.